関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 7-Iodo-1H-benzo[d][1,3]oxazine-2,4-dione | HCID 18929920 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | Methyl 2-amino-4-iodobenzoate | HCID 18929930 | 80.2% |
反応手順
To a stirred solution of sodium hydroxide (0.048 g, 1.2 mM) in methanol (4.5 mL) was added 7-iodo-2H-3,1-benzoxazine-2,4(1H)-dione (2.6 g, 9.0 mM). The mixture was heated at 60° C. for 7 hr and the resulting solution was cooled, poured into water and extracted with ethyl acetate. The combined extracts were washed once with dilute sodium hydroxide, dried (MgSO4), filtered and concentrated to leave the title compound (2.0 g, 80%) as a brown oil which slowly crystallized; MS(CI): 278 (M+H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05733910 |
|---|
| 出典データセット | uspto-grants-1998_03 |
|---|
| ORD ID | ord-c4712f788bc44516bf8778e183920013 |
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| 出典メモ | uspto-grants-1998_03 |
|---|
