2-Chloro-5-(trifluoromethyl)pyridine → 2-(2,3-Dihydro-2-phenyl-benzo[1,4]dioxin-6-yloxy)5-trifluoromethylpyridine

HRID 31220

反応式

HRID 31220 の反応式
[C:1]1([CH:7]2[O:12][C:11]3[CH:13]=[CH:14][C:15]([O:17][C:18]4[CH:23]=[CH:22][C:21]([N+]([O-])=O)=[CH:20][N:19]=4)=[CH:16][C:10]=3[O:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C1(C2OC3C=CC(O)=CC=3OC2)C=CC=CC=1.ClC1C=CC([C:51]([F:54])([F:53])[F:52])=CN=1>>[C:1]1([CH:7]2[O:12][C:11]3[CH:13]=[CH:14][C:15]([O:17][C:18]4[CH:23]=[CH:22][C:21]([C:51]([F:54])([F:53])[F:52])=[CH:20][N:19]=4)=[CH:16][C:10]=3[O:9][CH2:8]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

4

反応物 3

HCID 923422-Chloro-5-(trifluoromethyl)pyridineHCID 179785012-(2,3-Dihydro-2-phenyl-benzo[1,4]dioxin-6-yloxy)-5-nitropyridineHCID 179785732,3-Dihydro-2-phenyl-benzo[1,4]dioxin-6-ol

生成物 1

HCID 179785172-(2,3-Dihydro-2-phenyl-benzo[1,4]dioxin-6-yloxy)5-trifluoromethylpyridine

実験手順

2-(2,3-Dihydro-2-phenyl-benzo[1,4]dioxin-6-yloxy)5-trifluoromethylpyridine was prepared in the same way as 2-(2,3-dihydro-2-phenyl-benzo[1,4]dioxin-6-yloxy)-5-nitropyridine above from 2,3-dihydro-2-phenyl-benzo[1,4]dioxin-6-ol (80 mg) and 2-chloro-5-(trifluoromethyl)pyridine (64 mg). Yield is 50 mg and mp 104-110° C. 1H NMR (DMSO-d6) δ=4.15 (dd, J=8.3, 11.4Hz, 1H), 4.46 (dd, J=2.3, 11.4 Hz, 1H), 5.27 (dd, J=2.3, 8.3 Hz, 1H), 6.72 (dd, J=2.8, 8.8 Hz, 1H), 6.84 (d, J=2.8 Hz, 1H), 7.03 (d, J=8.8 Hz, 1H), 7.19 (d, J=8.8 Hz, 1H), 7.39-7.52 (m, 5H), 8.20 (dd, J=8.8, 2.6 Hz, 1H), 8.58 (d, J=2.6 Hz, 1H).

出典と根拠

ORDレコード
ord-e03c632522f941e9ae797a26c3ce7c77
出典データセット
uspto-grants-2008_09
特許番号
US07425568B2

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