(3-Cyano-5-fluorophenyl)boronic acid → 3-[(4,4-diethyl-1-methyl-2-oxo-1,4-dihydro-2H-3,1-benzoxazin-6-yl)amino]-5-fluorobenzonitrile

反応式

[F:18][c:19]1[cH:20][c:21]([C:28]#[N:29])[cH:22][c:23]([B:25]([OH:26])[OH:27])[cH:24]1.[NH2:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([cH:17]1)[C:7]([CH2:13][CH3:14])([CH2:15][CH3:16])[O:8][C:9](=[O:12])[N:10]2[CH3:11]>>[NH:1]([c:2]1[cH:3][cH:4][c:5]2[c:6]([cH:17]1)[C:7]([CH2:13][CH3:14])([CH2:15][CH3:16])[O:8][C:9](=[O:12])[N:10]2[CH3:11])[c:23]1[cH:22][c:21]([C:28]#[N:29])[cH:20][c:19]([F:18])[cH:24]1

参加物

反応物 2

HCID 23435605(3-Cyano-5-fluorophenyl)boronic acid

HCID 692163266-amino-4,4-diethyl-1-methyl-1,4-dihydro-2H-3,1-benzoxazin-2-one

生成物 1

HCID 113141843-[(4,4-diethyl-1-methyl-2-oxo-1,4-dihydro-2H-3,1-benzoxazin-6-yl)amino]-5-fluorobenzonitrile

出典と根拠

ORDレコード: ord-579ad2a862a245819d1b683069fe2083
出典データセット: Training data from https://doi.org/10.1039/C8SC04228D (8/10)
DOI: 10.1039/C8SC04228D

反応ノート

読み込み中…