化工社化工社 化学情報印刷レポート · 研究参考用
4-Bromoanisole → 5-Chloro-3-hydroxy-3-(4-methoxyphenyl)-1,3-dihydro-2H-indol-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Bromoanisole | HCID 7730 | — |
| 反応物 | 5-chloro-1H-indole-2,3-dione | HCID 87203 | — |
| 反応物 | Magnesium | HCID 5462224 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 5-Chloro-3-hydroxy-3-(4-methoxyphenyl)-1,3-dihydro-2H-indol-2-one | HCID 22560907 | 72.9% |
反応手順
This compound is prepared according to the procedure described in step A of Preparation 1.3 starting with 3.5 g of magnesium, 25 g of 1-bromo-4-methoxybenzene, 50 ml of THF and a mixture of 8 g of 5-chloro-1H-indol-2,3-dione in 50 ml of THF. 9.3 g of the expected product are obtained after crystallization from hot iso ether; m.p.=202° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07425566B2 |
| 出典データセット | uspto-grants-2008_09 |
| ORD ID | ord-86d7b71e15434408bfc215eb7ab4417b |
| 出典メモ | uspto-grants-2008_09 |