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5-chloro-1H-indole-2,3-dione → 5-Chloro-3-hydroxy-3-(3,5-dimethoxyphenyl)-1,3-dihydro-2H-indol-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-chloro-1H-indole-2,3-dione | HCID 87203 | — |
| 反応物 | 1-Bromo-3,5-dimethoxybenzene | HCID 639187 | — |
| 反応物 | Magnesium | HCID 5462224 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 5-Chloro-3-hydroxy-3-(3,5-dimethoxyphenyl)-1,3-dihydro-2H-indol-2-one | HCID 22560911 | 60.6% |
反応手順
This compound is prepared according to the procedure described in step A of Preparation 1.6, starting with 1.2 g of magnesium, 9.5 g of 1-bromo-3,5-dimethoxybenzene, 50 ml of THF and a solution of 3 g of 5-chloro-1H-indole-2,3-dione in 50 ml of THF. 3.2 g of the expected product are obtained after crystallization from iso ether; m.p.=191° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07425566B2 |
| 出典データセット | uspto-grants-2008_09 |
| ORD ID | ord-b91722a6d23c4616a697ac482eb50a9d |
| 出典メモ | uspto-grants-2008_09 |