2-Bromophenol → 1-(Benzyloxy)-2-bromobenzene
反応式
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[OH:8].[CH2:9](Cl)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.C([O-])([O-])=O.[K+].[K+]>CC(C)=O>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[O:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1参加物
5
実験手順
A mixture of 35 g of 1-bromo-2-hydroxy-benzene, 30.5 g of benzyl chloride and 50 g of K2CO3 in 500 ml of acetone is refluxed for 12 hours. The reaction mixture is concentrated under vacuum, the residue is taken up in a water/EtOAc mixture, the organic phase is washed with 1N NaOH solution and with water and dried over Na2SO4, and the solvent is evaporated off under vacuum. The resulting oil is distilled under reduced pressure to give 50.3 g of the expected product, b.p.=155° C. at 40 Pa.
後処理
- temperatureis refluxed for 12 hours
- concentrationThe reaction mixture is concentrated under vacuum
- washthe organic phase is washed with 1N NaOH solution and with water
- dry with materialdried over Na2SO4
- customthe solvent is evaporated off under vacuum
- distillationThe resulting oil is distilled under reduced pressure
出典と根拠
- ORDレコード
- ord-4bba665bcc164f27aa90061a113de7b7
- 出典データセット
- uspto-grants-2008_09
- 特許番号
- US07425566B2
反応ノート
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