関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Levofloxacin | HCID 149096 | — |
| 溶媒 | Methyl Ethyl Ketone | HCID 6569 | — |
| 生成物 | Levofloxacin Hydrate | HCID 3033924 | 84% |
反応手順
1.5 g of levofloxacin crude was put in suspension in 15 ml of MEK. The mixture was heated to reflux temperature until complete dissolution of the material. Then the solution was cooled to −5° C. over a period of 3 hours. The precipitate was filtrated under vacuum, washed with 1.5 ml of MEK and dried at 30° C. in a vacuum oven to give 840 mg (84%) of purified levofloxacin hemihydrate.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07425628B2 |
|---|
| 出典データセット | uspto-grants-2008_09 |
|---|
| ORD ID | ord-5ef30b4014b14c6b9ef8a9cf7daa197a |
|---|
| 出典メモ | uspto-grants-2008_09 |
|---|
