Morpholine → 4-(3-Nitrophenyl)morpholine

HRID 31400

反応式

HRID 31400 の反応式
F[C:2]1[CH:3]=[C:4]([N+:8]([O-:10])=[O:9])[CH:5]=[CH:6][CH:7]=1.[NH:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1>CS(C)=O>[N+:8]([C:4]1[CH:3]=[C:2]([N:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)[CH:7]=[CH:6][CH:5]=1)([O-:10])=[O:9]

参加物

4

反応物 2

HCID 8083MorpholineHCID 98231-Fluoro-3-nitrobenzene

生成物 1

HCID 12532734-(3-Nitrophenyl)morpholine

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

反応条件

温度
110 °C

実験手順

3-Fluoronitrobenzene (10 g, 71 mmol) was added to a solution of morpholine (34 ml, 390 mmol) in dimethylsulfoxide (120 ml) and heated at 110° C. for 60 hours. The reaction was cooled and poured onto water (800 ml). The desired product precipitated and was collected by filtration. The orange solid was dried in vacuo and used in subsequent reactions without further purification (13.7 g, 66 mmol).

後処理

  1. temperatureThe reaction was cooled
  2. additionpoured onto water (800 ml)
  3. customThe desired product precipitated
  4. filtrationwas collected by filtration
  5. customThe orange solid was dried in vacuo
  6. customused in subsequent reactions without further purification (13.7 g, 66 mmol)

出典と根拠

ORDレコード
ord-37b9b77e1244444086434082d264cf48
出典データセット
uspto-grants-2008_09
特許番号
US07425555B2

関連ノート

読み込み中…