Morpholine → 4-(3-Nitrophenyl)morpholine
反応式
F[C:2]1[CH:3]=[C:4]([N+:8]([O-:10])=[O:9])[CH:5]=[CH:6][CH:7]=1.[NH:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1>CS(C)=O>[N+:8]([C:4]1[CH:3]=[C:2]([N:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)[CH:7]=[CH:6][CH:5]=1)([O-:10])=[O:9]参加物
4
反応条件
- 温度
- 110 °C
実験手順
3-Fluoronitrobenzene (10 g, 71 mmol) was added to a solution of morpholine (34 ml, 390 mmol) in dimethylsulfoxide (120 ml) and heated at 110° C. for 60 hours. The reaction was cooled and poured onto water (800 ml). The desired product precipitated and was collected by filtration. The orange solid was dried in vacuo and used in subsequent reactions without further purification (13.7 g, 66 mmol).
後処理
- temperatureThe reaction was cooled
- additionpoured onto water (800 ml)
- customThe desired product precipitated
- filtrationwas collected by filtration
- customThe orange solid was dried in vacuo
- customused in subsequent reactions without further purification (13.7 g, 66 mmol)
出典と根拠
- ORDレコード
- ord-37b9b77e1244444086434082d264cf48
- 出典データセット
- uspto-grants-2008_09
- 特許番号
- US07425555B2
反応ノート
読み込み中…