関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dimethylamine | HCID 674 | — |
| 反応物 | Potassium Iodide | HCID 4875 | — |
| 反応物 | 2-(Chloromethyl)-5-(4-iodophenyl)-1,3,4-oxadiazole | HCID 7091068 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | [5-(4-Iodophenyl)-[1,3,4]oxadiazol-2-ylmethyl]-dimethylamine | HCID 69314787 | — |
反応手順
2-Chloromethyl-5-(4-iodophenyl)-[1,3,4]oxadiazole (Intermediate 7) (48 mg, 0.15 mmol) and potassium iodide (25 mg, 0.15 mmol) were dissolved in 2M dimethylamine in tetrahydrofuran (2 ml) and stirred for 18 hours at 20° C. The reaction was evaporated to dryness in vacuo and the product was purified on a 10 g silica SPE cartridge (stepped solvent gradient 80:20 ethyl acetate:cyclohexane, 100% ethyl acetate, 95:5 ethyl acetate:methanol).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07425555B2 |
|---|
| 出典データセット | uspto-grants-2008_09 |
|---|
| ORD ID | ord-c2559fa983e245c3a7bffa15abcab064 |
|---|
| 出典メモ | uspto-grants-2008_09 |
|---|
