反応式
Cl[CH2:2][C:3]1[O:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([I:14])=[CH:10][CH:9]=2)=[N:6][N:7]=1.[I-].[K+].[CH3:17][NH:18][CH3:19]>O1CCCC1>[I:14][C:11]1[CH:12]=[CH:13][C:8]([C:5]2[O:4][C:3]([CH2:2][N:18]([CH3:19])[CH3:17])=[N:7][N:6]=2)=[CH:9][CH:10]=1参加物
5
反応条件
- 温度
- 20 °C
実験手順
2-Chloromethyl-5-(4-iodophenyl)-[1,3,4]oxadiazole (Intermediate 7) (48 mg, 0.15 mmol) and potassium iodide (25 mg, 0.15 mmol) were dissolved in 2M dimethylamine in tetrahydrofuran (2 ml) and stirred for 18 hours at 20° C. The reaction was evaporated to dryness in vacuo and the product was purified on a 10 g silica SPE cartridge (stepped solvent gradient 80:20 ethyl acetate:cyclohexane, 100% ethyl acetate, 95:5 ethyl acetate:methanol).
後処理
- customThe reaction was evaporated to dryness in vacuo
- customthe product was purified on a 10 g silica SPE cartridge (stepped solvent gradient 80:20 ethyl acetate:cyclohexane, 100% ethyl acetate, 95:5 ethyl acetate:methanol)
出典と根拠
- ORDレコード
- ord-c2559fa983e245c3a7bffa15abcab064
- 出典データセット
- uspto-grants-2008_09
- 特許番号
- US07425555B2
関連ノート
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