化工社化工社 化学情報印刷レポート · 研究参考用
Dichloromethane → 4-bromo-N'-(2,2-dimethylpropanoyl)benzohydrazide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dichloromethane | HCID 6344 | — |
| 反応物 | Ammonium Chloride | HCID 25517 | — |
| 反応物 | 4-Bromobenzoyl chloride | HCID 68515 | — |
| 反応物 | tert-Butyl carbazate | HCID 70091 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 生成物 | 4-bromo-N'-(2,2-dimethylpropanoyl)benzohydrazide | HCID 4782693 | — |
反応手順
t-Butyloxycarbonylhydrazine (1.26 g) was added portionwise to a solution of 4-bromobenzoyl chloride (2.0 g), and DIPEA (2.37 ml) in DCM (20 ml) and the reaction stirred at room temperature for 18 hours. Ammonium chloride solution was added, the organic phase was separated, dried and the solvent evaporated under vacuum to give 4-bromo-benzoic acid N′-(2,2-dimethyl-propionyl)-hydrazide.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07425555B2 |
| 出典データセット | uspto-grants-2008_09 |
| ORD ID | ord-8132fc3f3dc447e5b26609efe5f81896 |
| 出典メモ | uspto-grants-2008_09 |