Tert-butyl 2-({5'-[(cyclopropylamino)carbonyl]-2'-methyl-1,1'-biphenyl-4-yl}carbonyl)hydrazinecarboxylate → N-cyclopropyl-4'-(hydrazinocarbonyl)-6-methyl-1,1'-biphenyl-3-carboxamide

HRID 31427

反応式

HRID 31427 の反応式
[CH:1]1([NH:4][C:5]([C:7]2[CH:8]=[CH:9][C:10]([CH3:30])=[C:11]([C:13]3[CH:18]=[CH:17][C:16]([C:19]([NH:21][NH:22]C(OC(C)(C)C)=O)=[O:20])=[CH:15][CH:14]=3)[CH:12]=2)=[O:6])[CH2:3][CH2:2]1>Cl>[CH:1]1([NH:4][C:5]([C:7]2[CH:12]=[C:11]([C:13]3[CH:18]=[CH:17][C:16]([C:19]([NH:21][NH2:22])=[O:20])=[CH:15][CH:14]=3)[C:10]([CH3:30])=[CH:9][CH:8]=2)=[O:6])[CH2:3][CH2:2]1

参加物

3

反応物 1

HCID 59263012Tert-butyl 2-({5'-[(cyclopropylamino)carbonyl]-2'-methyl-1,1'-biphenyl-4-yl}carbonyl)hydrazinecarboxylate2 回

生成物 1

HCID 11438287N-cyclopropyl-4'-(hydrazinocarbonyl)-6-methyl-1,1'-biphenyl-3-carboxamide

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

A solution of tert-butyl 2-({5′-[(cyclopropylamino)carbonyl]-2′-methyl-1,1′-biphenyl-4-yl}carbonyl)hydrazinecarboxylate (Intermediate 41) (2.37 g) in hydrogen chloride (4.0M solution in dioxane, 20 ml) was stirred at room temperature under nitrogen for 6 hours. The solvent was evaporated under vacuum, the residue was dissolved in water, basified with sodium hydroxide solution (2N) and extracted with ethyl acetate. The organic phase was dried (magnesium sulphate) and the solvent removed under vacuum to give the N-cyclopropyl-4′-(hydrazinocarbonyl)-6-methyl-1,1′-biphenyl-3-carboxamide.

後処理

  1. customThe solvent was evaporated under vacuum
  2. dissolutionthe residue was dissolved in water
  3. extractionextracted with ethyl acetate
  4. dry with materialThe organic phase was dried (magnesium sulphate)
  5. customthe solvent removed under vacuum

出典と根拠

ORDレコード
ord-abae4452f6fe457aab21c76e4e460e8b
出典データセット
uspto-grants-2008_09
特許番号
US07425555B2

関連ノート

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