4-(4-Bromophenyl)-1,3-thiazol-2-amine hydrobromide → 4'-(2-Amino-4-thiazolyl)-N-cyclopropyl-6-methyl[1,1'-biphenyl]-3-carboxamide
反応式
Br.Br[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]=[C:11]([NH2:14])[S:12][CH:13]=2)=[CH:5][CH:4]=1.[CH:15]1([NH:18][C:19](=[O:36])[C:20]2[CH:25]=[CH:24][C:23]([CH3:26])=[C:22](B3OC(C)(C)C(C)(C)O3)[CH:21]=2)[CH2:17][CH2:16]1>>[NH2:14][C:11]1[S:12][CH:13]=[C:9]([C:6]2[CH:7]=[CH:8][C:3]([C:22]3[C:23]([CH3:26])=[CH:24][CH:25]=[C:20]([C:19]([NH:18][CH:15]4[CH2:17][CH2:16]4)=[O:36])[CH:21]=3)=[CH:4][CH:5]=2)[N:10]=1参加物
3
実験手順
Example 5 was prepared using 4-(4-bromophenyl)-2-thiazolamine monohydrobromide and N-cyclopropyl-4-methyl-3-(4,4,5,5-tetramethyl-[1,3,2]-dioxaborolan-2-yl)benzamide (Intermediate 17).
後処理
- customExample 5 was prepared
出典と根拠
- ORDレコード
- ord-5569531ec12c41d68b2a7e962e376807
- 出典データセット
- uspto-grants-2008_09
- 特許番号
- US07425555B2
反応ノート
読み込み中…