2-(4-Bromo-3-methylphenyl)-5-methyl-1,3,4-oxadiazole → 6,2'-Dimethyl-4'-(5-methyl-[1,3,4]oxadiazol-2-yl)-biphenyl-3-carboxylic acid thiazol-2-ylamide

HRID 31448

反応式

HRID 31448 の反応式
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([CH3:13])=[N:11][N:12]=2)=[CH:4][C:3]=1[CH3:14].CC1(C)C(C)(C)OB(C2C=CC=CC=2C(NC2SC=CN=2)=O)O1.[CH3:38][C:39]1[CH:52]=[CH:51][C:42]([C:43]([NH:45][C:46]2[S:47][CH:48]=[CH:49][N:50]=2)=[O:44])=[CH:41][C:40]=1B1OC(C)(C)C(C)(C)O1>>[S:47]1[CH:48]=[CH:49][N:50]=[C:46]1[NH:45][C:43]([C:42]1[CH:41]=[C:40]([C:2]2[CH:7]=[CH:6][C:5]([C:8]3[O:9][C:10]([CH3:13])=[N:11][N:12]=3)=[CH:4][C:3]=2[CH3:14])[C:39]([CH3:38])=[CH:52][CH:51]=1)=[O:44]

参加物

4

反応物 3

HCID 114366932-(4-Bromo-3-methylphenyl)-5-methyl-1,3,4-oxadiazoleHCID 219145174-Methyl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-N-(thiazol-2-yl)-benzamideHCID 866046964,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl-N-(thiazol-2-yl)-benzamide

生成物 1

HCID 102498106,2'-Dimethyl-4'-(5-methyl-[1,3,4]oxadiazol-2-yl)-biphenyl-3-carboxylic acid thiazol-2-ylamide

実験手順

Example 19 was prepared using 2-(4-bromo-3-methylphenyl)-5-methyl-[1,3,4]oxadiazole and 4-methyl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl-N-(thiazol-2-yl)-benzamide (Intermediate 22).

後処理

  1. customExample 19 was prepared

出典と根拠

ORDレコード
ord-5d4f27f013974c239b0c96184fbc9768
出典データセット
uspto-grants-2008_09
特許番号
US07425555B2

関連ノート

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