Sodium ethoxide → HCID 86604697、化合物

HRID 31469

反応式

HRID 31469 の反応式
[O-]CC.[Na+].ClCC1OC([C:12]2[CH:17]=[CH:16][C:15]([C:18]3[C:23]([CH3:24])=[C:22]([F:25])[CH:21]=[C:20]([C:26]([NH:28]C4CC4)=[O:27])[CH:19]=3)=[CH:14][CH:13]=2)=NN=1>C(O)C>[F:25][C:22]1[CH:21]=[C:20]([C:26]([NH2:28])=[O:27])[CH:19]=[C:18]([C:15]2[CH:16]=[CH:17][CH:12]=[CH:13][CH:14]=2)[C:23]=1[CH3:24]

参加物

4

反応物 2

HCID 2723922Sodium ethoxideHCID 693149174'-[5-(chloromethyl)-1,3,4-oxadiazol-2-yl]-N-cyclopropyl-5-fluoro-6-methyl-1,1'-biphenyl-3-carboxamide2 回

生成物 1

HCID 86604697HCID 86604697、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒2 回

実験手順

Freshly prepared sodium ethoxide in ethanol (0.2M, 0.8 ml) was added to a solution of (4′-[5-(chloromethyl)-1,3,4-oxadiazol-2-yl]-N-cyclopropyl-5-fluoro-6-methyl-1,1′-biphenyl-3-carboxamide (Intermediate 34) (50 mg) in ethanol (1 ml) and the reaction stirred at room temperature for 18 hours. The reaction was reduced to dryness under vacuum and the residue partitioned between ethyl acetate and water. The organic phase dried (magnesium sulphate) and reduced to dryness under vacuum. The residue was purified by HPLC to give N-cyclopropyl-4′-[5-ethoxymethyl)-1,3,4-oxadiazol-2-yl]-5-fluoro-6-methyl-1,1′-biphenyl-3-carboxamide.

後処理

  1. customthe residue partitioned between ethyl acetate and water
  2. dry with materialThe organic phase dried (magnesium sulphate)
  3. customThe residue was purified by HPLC

出典と根拠

ORDレコード
ord-01140e8d3fa24085a648bb18a36c93a3
出典データセット
uspto-grants-2008_09
特許番号
US07425555B2

関連ノート

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