Benzoyl chloride → 3-cyano-N-[4-(benzoylamino)-benzyl]-benzamide

HRID 31499ノート

反応式

HRID 31499 の反応式
[C:1](Cl)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:10]([C:12]1[CH:13]=[C:14]([CH:26]=[CH:27][CH:28]=1)[C:15]([NH:17][CH2:18][C:19]1[CH:24]=[CH:23][C:22]([NH2:25])=[CH:21][CH:20]=1)=[O:16])#[N:11].C(N(CC)CC)C>C(Cl)Cl>[C:10]([C:12]1[CH:13]=[C:14]([CH:26]=[CH:27][CH:28]=1)[C:15]([NH:17][CH2:18][C:19]1[CH:24]=[CH:23][C:22]([NH:25][C:1](=[O:8])[C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[CH:21][CH:20]=1)=[O:16])#[N:11]

参加物

5

反応物 3

HCID 7412Benzoyl chlorideHCID 8471TriethylamineHCID 608931683-cyano-N-(4-amino-benzyl)-benzamide

生成物 1

HCID 693086213-cyano-N-[4-(benzoylamino)-benzyl]-benzamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

A solution of 0.6 g (4.2 mmol) of benzoylchloride in 10 ml of methylene chloride is added dropwise to a solution of 1 g (4 mmol) of 3-cyano-N-(4-amino-benzyl)-benzamide and 0.6 g (6 mmol) of triethylamine in 30 ml of methylene chloride at ambient temperature. After 8 hours at ambient temperature the product which has crystallised out is dissolved in methylene chloride and methanol. After extraction with water the combined organic extracts are dried and evaporated down.

後処理

  1. customAfter 8 hours at ambient temperature the product which has crystallised out
  2. dissolutionis dissolved in methylene chloride
  3. extractionAfter extraction with water the combined organic extracts
  4. customare dried
  5. customevaporated down

出典と根拠

ORDレコード
ord-2bed51339cdf4881b929757cb7991d35
出典データセット
uspto-grants-2008_09
特許番号
US07425641B2

反応ノート

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