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Methyl triflate → 4-(2-Methyl-imidazole-1-sulfonyl)-piperazine-1-carboxylic acid tert-butyl ester triflate salt
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl triflate | HCID 9526 | — |
| 反応物 | 4-(2-Methyl-imidazole-1-sulfonyl)-piperazine-1-carboxylic acid tert-butyl ester | HCID 69273758 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 4-(2-Methyl-imidazole-1-sulfonyl)-piperazine-1-carboxylic acid tert-butyl ester triflate salt | HCID 86595527 | — |
反応手順
A solution of 4-(2-methyl-imidazole-1-sulfonyl)-piperazine-1-carboxylic acid tert-butyl ester (1.4 g, 4.24 mmol) in methylene chloride was cooled in an ice bath, and trifluoromethanesulfonic acid methyl ester (0.56 mL, 4.9 mmol) was added via a pipet. After stirring at ice temperature for 3 h, the solvent was evaporated to give 4-(2-methyl-imidazole-1-sulfonyl)-piperazine-1-carboxylic acid tert-butyl ester triflate salt as yellow solids.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07425638B2 |
| 出典データセット | uspto-grants-2008_09 |
| ORD ID | ord-38fad87017304b2ea8cf82845de81665 |
| 出典メモ | uspto-grants-2008_09 |