Hydrochloric Acid → [4,5-Bis-(4-chloro-phenyl)-2-(2-ethoxy-4-trifluoromethyl-phenyl)-4,5-dihydro-imidazol-1-yl]-(piperazin-1-yl)-methanone hydrochloride

HRID 31513ノート

反応式

HRID 31513 の反応式
Cl.[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[CH:13]([C:14]3[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=3)[N:12]([C:21]([N:23]3[CH2:28][CH2:27][N:26](C(OC(C)(C)C)=O)[CH2:25][CH2:24]3)=[O:22])[C:11]([C:36]3[CH:41]=[CH:40][C:39]([C:42]([F:45])([F:44])[F:43])=[CH:38][C:37]=3[O:46][CH2:47][CH3:48])=[N:10]2)=[CH:5][CH:4]=1>O1CCOCC1>[ClH:2].[Cl:2][C:3]1[CH:4]=[CH:5][C:6]([CH:9]2[CH:13]([C:14]3[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=3)[N:12]([C:21]([N:23]3[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]3)=[O:22])[C:11]([C:36]3[CH:41]=[CH:40][C:39]([C:42]([F:44])([F:43])[F:45])=[CH:38][C:37]=3[O:46][CH2:47][CH3:48])=[N:10]2)=[CH:7][CH:8]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 69275683[4,5-Bis-(4-chloro-phenyl)-2-(2-ethoxy-4-trifluoromethyl-phenyl)-4,5-dihydro-imidazol-1-yl]-[4-tert-butyloxycarbonylpiperazin-1-yl]-methanone

生成物 1

HCID 86595528[4,5-Bis-(4-chloro-phenyl)-2-(2-ethoxy-4-trifluoromethyl-phenyl)-4,5-dihydro-imidazol-1-yl]-(piperazin-1-yl)-methanone hydrochloride収率 98%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

Hydrochloric acid (10 mL, 40 mmol, 4 M in 1,4-dioxane) was added to a cooled (0° C.) solution of [4,5-bis-(4-chloro-phenyl)-2-(2-ethoxy-4-trifluoromethyl-phenyl)-4,5-dihydro-imidazol-1-yl]-[4-tert-butyloxycarbonylpiperazin-1-yl]-methanone in 1,4-dioxane (10 mL). The mixture was stirred at room temperature overnight. Evaporation of the solvent gave [4,5-bis-(4-chloro-phenyl)-2-(2-ethoxy-4-trifluoromethyl-phenyl)-4,5-dihydro-imidazol-1-yl]-(piperazin-1-yl)-methanone hydrochloride as an off-white solid (1.10 g, 98% yield).

後処理

  1. customEvaporation of the solvent

出典と根拠

ORDレコード
ord-926c1b9483964e2bad38888322e96e6d
出典データセット
uspto-grants-2008_09
特許番号
US07425638B2

反応ノート

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