Dimethyl Sulfoxide → 3-[(4-Chlorophenyl)-[3-[2-fluoro-1-(3-fluoro-5-imidazol-1-ylphenyl)-2-methylpropyl]azetidin-1-yl]methyl]benzonitrile

反応式

[CH3:46][S:47]([CH3:48])=[O:49].[Cl:1][c:2]1[cH:3][cH:4][c:5]([CH:8]([c:9]2[cH:10][c:11]([C:12]#[N:13])[cH:14][cH:15][cH:16]2)[N:17]2[CH2:18][CH:19]([CH:21]([C:22]([CH3:23])([CH3:24])[F:25])[c:26]3[cH:27][c:28]([F:33])[cH:29][c:30]([F:32])[cH:31]3)[CH2:20]2)[cH:6][cH:7]1.[K+:39].[K+:40].[O-:41][C:42]([O-:43])=[O:44].[OH2:45].[nH:34]1[cH:35][n:36][cH:37][cH:38]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([CH:8]([c:9]2[cH:10][c:11]([C:12]#[N:13])[cH:14][cH:15][cH:16]2)[N:17]2[CH2:18][CH:19]([CH:21]([C:22]([CH3:23])([CH3:24])[F:25])[c:26]3[cH:27][c:28]([F:33])[cH:29][c:30](-[n:34]4[cH:35][n:36][cH:37][cH:38]4)[cH:31]3)[CH2:20]2)[cH:6][cH:7]1