(2,2-Diethyl-1,3-dioxan-5-yl)methanol → 2-(((4-((2,2-Diethyl-1,3-dioxan-5-yl)methoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt

HRID 31630

反応式

HRID 31630 の反応式
[Na:1].COC1OCC(CO[C:12]2[CH:17]=[CH:16][N:15]=[C:14]([CH2:18][S:19]([C:21]3[NH:25][C:24]4[CH:26]=[CH:27][CH:28]=[CH:29][C:23]=4[N:22]=3)=[O:20])[C:13]=2[CH3:30])CO1.[CH2:31]([C:33]1([CH2:41][CH3:42])[O:38][CH2:37][CH:36]([CH2:39][OH:40])[CH2:35][O:34]1)[CH3:32]>>[Na:1].[CH2:41]([C:33]1([CH2:31][CH3:32])[O:34][CH2:35][CH:36]([CH2:39][O:40][C:12]2[CH:17]=[CH:16][N:15]=[C:14]([CH2:18][S:19]([C:21]3[NH:25][C:24]4[CH:26]=[CH:27][CH:28]=[CH:29][C:23]=4[N:22]=3)=[O:20])[C:13]=2[CH3:30])[CH2:37][O:38]1)[CH3:42]

参加物

3

反応物 2

HCID 14629254(2,2-Diethyl-1,3-dioxan-5-yl)methanolHCID 667760022-(((4-((2-Methoxy-1,3-dioxan-5-yl)methoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt

生成物 1

HCID 667766792-(((4-((2,2-Diethyl-1,3-dioxan-5-yl)methoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt収率 9.7%

実験手順

The same procedure as in the steps (6b) to (6f) of Example 6 was repeated using (2,2-diethyl-1,3-dioxan-5-yl)methanol obtained in the step (23a) to obtain the title compound (164 mg, total yield: 9.7%) as a light yellow solid.

後処理

  1. customobtained in the step (23a)

出典と根拠

ORDレコード
ord-81a9d7e6c383445ba117fb9ce0154a93
出典データセット
uspto-grants-2008_09
特許番号
US07425634B2

関連ノート

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