2,2-Dimethyl-1,3-dioxan-5-ol → 2-(((4-((2,2-Dimethyl-1,3-dioxan-5-yl)oxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt

HRID 31635

反応式

HRID 31635 の反応式
COC1OCC(C[O:10][C:11]2[CH:16]=[CH:15][N:14]=[C:13]([CH2:17][S:18]([C:20]3[NH:24][C:23]4[CH:25]=[CH:26][CH:27]=[CH:28][C:22]=4[N:21]=3)=[O:19])[C:12]=2[CH3:29])CO1.[Na:30].COC1OCC(COC2C=CN=C(CS(C3NC4C=CC=CC=4N=3)=O)C=2C)CO1.[CH3:60][C:61]1([CH3:68])[O:66][CH2:65][CH:64](O)[CH2:63][O:62]1>>[Na:30].[CH3:60][C:61]1([CH3:68])[O:66][CH2:65][CH:64]([O:10][C:11]2[CH:16]=[CH:15][N:14]=[C:13]([CH2:17][S:18]([C:20]3[NH:21][C:22]4[CH:28]=[CH:27][CH:26]=[CH:25][C:23]=4[N:24]=3)=[O:19])[C:12]=2[CH3:29])[CH2:63][O:62]1

参加物

4

反応物 3

HCID 110298842,2-Dimethyl-1,3-dioxan-5-olHCID 120031202-(((4-((2-methoxy-1,3-dioxan-5-yl)methoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1H-benzimidazoleHCID 667760022-(((4-((2-Methoxy-1,3-dioxan-5-yl)methoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt

生成物 1

HCID 667759132-(((4-((2,2-Dimethyl-1,3-dioxan-5-yl)oxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt収率 18%

実験手順

The same procedure as in the steps (6d), (6e), and (6f) of Example 6 was repeated using 2,2-dimethyl-1,3-dioxan-5-ol obtained in the step (9a) to obtain the title compound (530 mg, total yield: 18%) as a light yellow solid.

後処理

  1. customobtained in the step (9a)

出典と根拠

ORDレコード
ord-2863493538bb45359a9d297d96b2f23a
出典データセット
uspto-grants-2008_09
特許番号
US07425634B2

関連ノート

読み込み中…