1,4-Dioxaspiro(4.5)decan-8-ol → 2-(((4-(1,4-Dioxaspiro[4.5]dec-8-yloxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt

HRID 31636

反応式

HRID 31636 の反応式
[Na:1].COC1O[CH2:8][CH:7]([CH2:10][O:11][C:12]2[CH:17]=[CH:16][N:15]=[C:14]([CH2:18][S:19]([C:21]3[NH:25][C:24]4[CH:26]=[CH:27][CH:28]=[CH:29][C:23]=4[N:22]=3)=[O:20])[C:13]=2[CH3:30])CO1.[O:31]1[C:35]2(CCC(O)[CH2:37][CH2:36]2)[O:34][CH2:33][CH2:32]1>>[Na:1].[O:31]1[C:35]2([CH2:36][CH2:37][CH:10]([O:11][C:12]3[CH:17]=[CH:16][N:15]=[C:14]([CH2:18][S:19]([C:21]4[NH:22][C:23]5[CH:29]=[CH:28][CH:27]=[CH:26][C:24]=5[N:25]=4)=[O:20])[C:13]=3[CH3:30])[CH2:7][CH2:8]2)[O:34][CH2:33][CH2:32]1

参加物

3

反応物 2

HCID 5673521,4-Dioxaspiro(4.5)decan-8-olHCID 667760022-(((4-((2-Methoxy-1,3-dioxan-5-yl)methoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt

生成物 1

HCID 667760182-(((4-(1,4-Dioxaspiro[4.5]dec-8-yloxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt収率 7.3%

実験手順

The same procedure as in the steps (6b) to (6f) of Example 6 was repeated using 1,4-dioxaspiro[4.5]decan-8-ol obtained in the step (27a) to obtain the title compound (230 mg, total yield: 7.3%) as a light yellow solid.

後処理

  1. customobtained in the step (27a)

出典と根拠

ORDレコード
ord-380c7708f36f419d9928cc628ccd408a
出典データセット
uspto-grants-2008_09
特許番号
US07425634B2

関連ノート

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