2-Aminopyrimidine-5-boronic acid, pinacol ester → 4-[6-Methyl-4-(4-trifluoromethyl-phenyl)-pyridin-2-yl]-[2,5']bipyrimidinyl-2'-ylamine

反応式

[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6](-[c:8]2[n:9][c:10]([CH3:24])[cH:11][c:12](-[c:14]3[cH:15][cH:16][c:17]([C:20]([F:21])([F:22])[F:23])[cH:18][cH:19]3)[cH:13]2)[n:7]1.[NH2:25][c:26]1[n:27][cH:28][c:29]([B:32]2[O:33][C:34]([CH3:35])([CH3:36])[C:37]([CH3:38])([CH3:39])[O:40]2)[cH:30][n:31]1>>[c:2]1(-[c:29]2[cH:28][n:27][c:26]([NH2:25])[n:31][cH:30]2)[n:3][cH:4][cH:5][c:6](-[c:8]2[n:9][c:10]([CH3:24])[cH:11][c:12](-[c:14]3[cH:15][cH:16][c:17]([C:20]([F:21])([F:22])[F:23])[cH:18][cH:19]3)[cH:13]2)[n:7]1

参加物

反応物 2

HCID 177502122-Aminopyrimidine-5-boronic acid, pinacol ester

HCID 574687972-Chloro-4-[6-methyl-4-(4-trifluoromethylphenyl)-pyridin-2-yl]-pyrimidine

生成物 1

HCID 247604364-[6-Methyl-4-(4-trifluoromethyl-phenyl)-pyridin-2-yl]-[2,5']bipyrimidinyl-2'-ylamine

出典と根拠

ORDレコード: ord-b446ecad6dac46afbc8df6dc4134b414
出典データセット: Training data from https://doi.org/10.1039/C8SC04228D (8/10)
DOI: 10.1039/C8SC04228D

反応ノート

読み込み中…