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HRID 31820作成日：2026年10月27日
Dimethylformamide → [4-(2,4-Dichlorophenyl)-5-imidazol-2-ylpyrimidin-2-yl]{2-[(6-methoxy-5-nitro(2-pyridyl)) amino]ethyl}amine
https://huagongshe.com/reaction/31820
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | 6-Chloro-2-methoxy-3-nitropyridine | HCID 10797703 | — |
| 反応物 | 4-(2,4-Dichlorophenyl)-5-imidazolylpyrimidin-2-ylethylamine | HCID 54231773 | — |
| 生成物 | [4-(2,4-Dichlorophenyl)-5-imidazol-2-ylpyrimidin-2-yl]{2-[(6-methoxy-5-nitro(2-pyridyl)) amino]ethyl}amine | HCID 22142635 | — |
反応手順
To a solution of [4-(2,4-dichlorophenyl)-5-imidazol-2-ylpyrimidin-2-ylethylamine (20 mg, 0.04 mmol) in DMF (1 ml), 2-methoxy-3-nitro-6-chloro-pyridine (8.3 mg, 0.04 mmol) and diisopropylethyl amine (31 μl, 0.18 mmol) were added. The reaction mixture was stirred for 12 hours at 80° C. The crude mixture was concentrated in vacuo and subjected to column chromatography (10% methanol in methylene chloride) to afford [4-(2,4-dichlorophenyl)-5-imidazol-2-ylpyrimidin-2-yl]{2-[(6-methoxy-5-nitro(2-pyridyl))-amino]ethyl}amine as bright yellow solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US07425557B2 |
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| 出典データセット | uspto-grants-2008_09 |
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| ORD ID | ord-351c0e8e60d64b93b02b64e94b9240be |
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| 出典メモ | uspto-grants-2008_09 |
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