Dimethylamine → 6-(2,6-dichlorophenyl)-2-(dimethylamino)-8-methyl-7H,8H-pyrido[2,3-d]pyrimidin-7-one

反応式

[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[C:9]1[C:20](=[O:21])[N:19]([CH3:22])[C:12]2[N:13]=[C:14](SC)[N:15]=[CH:16][C:11]=2[CH:10]=1.[CH3:23][NH:24][CH3:25]>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[C:9]1[C:20](=[O:21])[N:19]([CH3:22])[C:12]2[N:13]=[C:14]([N:24]([CH3:25])[CH3:23])[N:15]=[CH:16][C:11]=2[CH:10]=1

参加物

反応物 2

HCID 674Dimethylamine

HCID 107367016-(2,6-Dichlorophenyl)-8-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one

生成物 1

HCID 53278756-(2,6-dichlorophenyl)-2-(dimethylamino)-8-methyl-7H,8H-pyrido[2,3-d]pyrimidin-7-one

実験手順

This compound was prepared by a procedure similar to that described in Example 40 starting with 6-(2,6-dichlorophenyl)-8-methyl-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one of Example 37 and dimethylamine gas; mp 256°-258° C.

後処理

customThis compound was prepared by a procedure similar to

出典と根拠

ORDレコード: ord-3649f27493174d968301ce7cf9e817e4
出典データセット: uspto-grants-1998_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05733914

反応ノート

読み込み中…

参加物