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HRID 31876作成日：2026年10月26日

4-(Trifluoromethyl)benzoyl chloride → 6-{[2-({5-Imidazol-2-yl-4-[4-(trifluoromethyl)phenyl]pyrimidin-2-yl}amino)ethyl]-amino}pyridine-3-carbonitrile

https://huagongshe.com/reaction/31876

反応式

関与物質

役割名称HCID仕込み量
反応物4-(Trifluoromethyl)benzoyl chlorideHCID 67607—
反応物6-Chloro-3-pyridinecarbonitrileHCID 5152094—
反応物Chir-98023HCID 9847557—
生成物6-{[2-({5-Imidazol-2-yl-4-[4-(trifluoromethyl)phenyl]pyrimidin-2-yl}amino)ethyl]-amino}pyridine-3-carbonitrileHCID 22142493—

反応手順

b 6-{[2-({5-imidazol-2-yl-4-[4-(trifluoromethyl)phenyl]pyrimidin-2-yl}amino)ethyl]-amino}pyridine-3-carbonitrile was prepared from 4-(trifluoromethyl)benzoyl chloride and 2-chloro-5-(cyano)pyridine using the general method for [4-(2,4-dichlorophenyl)-5-imidazol-2-ylpyrimidin-2-yl]{2-[(5-nitro(2-pyridyl))amino]ethyl}amine.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07425557B2
出典データセットuspto-grants-2008_09
ORD IDord-5644389144a8421785b01900d6826ba8
出典メモuspto-grants-2008_09