4-Ethylbenzoyl chloride → 6-[(2-{[4-(4-Ethylphenyl)-5-imidazol-2-ylpyrimidin-2-yl]amino}ethyl)amino]-pyridine-3-carbonitrile
反応式
[CH2:1]([C:3]1[CH:11]=[CH:10][C:6]([C:7](Cl)=O)=[CH:5][CH:4]=1)[CH3:2].Cl[C:13]1[CH:18]=[CH:17][C:16]([C:19]#[N:20])=[CH:15][N:14]=1.ClC1C=C(Cl)C=CC=1C1[C:34]([C:35]2[NH:36][CH:37]=[CH:38][N:39]=2)=[CH:33][N:32]=[C:31]([NH:40][CH2:41][CH2:42][NH:43]C2C=CC([N+]([O-])=O)=CN=2)[N:30]=1>>[CH2:1]([C:3]1[CH:11]=[CH:10][C:6]([C:7]2[C:34]([C:35]3[NH:36][CH:37]=[CH:38][N:39]=3)=[CH:33][N:32]=[C:31]([NH:40][CH2:41][CH2:42][NH:43][C:13]3[N:14]=[CH:15][C:16]([C:19]#[N:20])=[CH:17][CH:18]=3)[N:30]=2)=[CH:5][CH:4]=1)[CH3:2]参加物
4
実験手順
6-[(2-{[4-(4-ethylphenyl)-5-imidazol-2-ylpyrimidin-2-yl]amino}ethyl)amino]-pyridine-3-carbonitrile was prepared from 4-ethylbenzoyl chloride and 2-chloro-5-(cyano)pyridine using the general method for [4-(2,4-dichlorophenyl)-5-imidazol-2-ylpyrimidin-2-yl]{2-[(5-nitro(2-pyridyl))amino]ethyl}amine.