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2-Chloro-5-nitropyridine → 4-[3-Imidazolyl-6-({2-[(5-nitro(2-pyridyl))amino]ethyl}amino)-2-pyridyl]benzene-carbonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Chloro-5-nitropyridine | HCID 78308 | — |
| 反応物 | 4-(Bromoacetyl)benzonitrile | HCID 98654 | — |
| 反応物 | Ceric ammonium nitrate | HCID 180504 | — |
| 反応物 | {2-[(6-Amino-5-nitro(2-pyridyl))amino]ethyl}[6-(2,4-dichlorophenyl)-5-imidazolyl(2-pyridyl)]amine | HCID 22142808 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 4-[3-Imidazolyl-6-({2-[(5-nitro(2-pyridyl))amino]ethyl}amino)-2-pyridyl]benzene-carbonitrile | HCID 22142958 | — |
反応手順
4-[3-imidazolyl-6-({2-[(5-nitro(2-pyridyl))amino]ethyl}amino)-2-pyridyl]Benzenecarbonitrile was prepared from 4-cyanophenacyl bromide, CAN for the oxidation (1:1 acetic acid and water with heating at 80° C. for 1 hour), and 2-chloro-5-nitropyridine using the general method for {2-[(6-amino-5-nitro(2-pyridyl))amino]ethyl}[6-(2,4-dichlorophenyl)-5-imidazolyl(2-pyridyl)]amine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07425557B2 |
| 出典データセット | uspto-grants-2008_09 |
| ORD ID | ord-1edb383ab3cc4fde8e34fdcb39c74736 |
| 出典メモ | uspto-grants-2008_09 |