Imidazole → Tert-butyl(chroman-4-yloxy)dimethylsilane

HRID 32064

反応式

HRID 32064 の反応式
[C:1]([Si:5](Cl)([CH3:7])[CH3:6])([CH3:4])([CH3:3])[CH3:2].[O:9]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:12]([OH:19])[CH2:11][CH2:10]1.CN1CCOCC1.N1C=CN=C1>C(Cl)Cl>[C:1]([Si:5]([O:19][CH:12]1[C:13]2[C:18](=[CH:17][CH:16]=[CH:15][CH:14]=2)[O:9][CH2:10][CH2:11]1)([CH3:7])[CH3:6])([CH3:4])([CH3:3])[CH3:2]

参加物

6

反応物 4

HCID 795ImidazoleHCID 79724-MethylmorpholineHCID 28928tert-Butyldimethylsilyl chlorideHCID 92890Chroman-4-ol

生成物 1

HCID 18448670Tert-butyl(chroman-4-yloxy)dimethylsilane

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

tert-Butyl-chloro-dimethyl-silane (10.54 g, 70 mmol) was added to a CH2Cl2 (200 mL) solution of 4-chromanol (10.00 g, 66.6 mmol), N-methylmorpholine (10.98 mL, 100 mmol) and imidazole (0.20 g, 3 mmol) at 0° C. The mixture was stirred for 3 days at RT. The reaction was diluted with CH2Cl2 (200 mL), washed with dilute HCl and H2O, dried over MgSO4, filtered, and concentrated in vacuo to provide the title compound.

後処理

  1. washwashed with dilute HCl and H2O
  2. dry with materialdried over MgSO4
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-8fbaecf91b4346379115785c32c01434
出典データセット
uspto-grants-2008_09
特許番号
US07425631B2

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