1,2-Dichloroethane → Trifluoro-methanesulfonic acid 5-[3-phenyl-3-(3-trifluoromethyl-benzenesulfonylamino)-propionylamino]-5,6,7,8-tetrahydro-naphthalen-2-yl Ester

HRID 32106ノート

反応式

HRID 32106 の反応式
[C:1]1([CH:7]([NH:12][S:13]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([C:22]([F:25])([F:24])[F:23])[CH:17]=2)(=[O:15])=[O:14])[CH2:8][C:9](O)=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:26][CH:27]1[CH2:36][CH2:35][CH2:34][C:33]2[CH:32]=[C:31]([O:37][S:38]([C:41]([F:44])([F:43])[F:42])(=[O:40])=[O:39])[CH:30]=[CH:29][C:28]1=2.C1C=CC2N(O)N=NC=2C=1.C(Cl)CCl>C(Cl)Cl>[C:1]1([CH:7]([NH:12][S:13]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([C:22]([F:24])([F:23])[F:25])[CH:17]=2)(=[O:15])=[O:14])[CH2:8][C:9]([NH:26][CH:27]2[CH2:36][CH2:35][CH2:34][C:33]3[CH:32]=[C:31]([O:37][S:38]([C:41]([F:44])([F:42])[F:43])(=[O:40])=[O:39])[CH:30]=[CH:29][C:28]2=3)=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

6

反応物 4

HCID 111,2-DichloroethaneHCID 757711-HydroxybenzotriazoleHCID 454390913-Phenyl-3-(3-trifluoromethyl-benzenesulfonylamino)-propionic acidHCID 59486419Trifluoromethanesulfonic acid 5-amino-5,6,7,8-tetrahydronaphthalen-2-yl ester

生成物 1

HCID 86598505Trifluoro-methanesulfonic acid 5-[3-phenyl-3-(3-trifluoromethyl-benzenesulfonylamino)-propionylamino]-5,6,7,8-tetrahydro-naphthalen-2-yl Ester

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

To a solution of 3-phenyl-3-(3-trifluoromethyl-benzenesulfonylamino)-propionic acid (4.31 g, 11.56 mmol), trifluoro-methanesulfonic acid 5-amino-5,6,7,8-tetrahydro-naphthalen-2-yl ester (Step D, 3.10 g, 10.51 mmol), HOBt (Aldrich, 1.28 g, 9.46 mmol), and CH2Cl2 (30 mL) was added EDC (Aldrich, 3.02 g, 15.76 mmol). The reaction was stirred at RT overnight and diluted with CH2Cl2 (100 mL). The organic phase was washed with saturated NaHCO3, water and brine, dried over Na2SO4, filtered and concentrated in vacuo. The crude was purified by silica gel chromatography (16-30% EtOAc-hexane) to afford the title compound as an off-white solid. MS (ESI): 651 (M+H)+.

後処理

  1. washThe organic phase was washed with saturated NaHCO3, water and brine
  2. dry with materialdried over Na2SO4
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo
  5. customThe crude was purified by silica gel chromatography (16-30% EtOAc-hexane)

出典と根拠

ORDレコード
ord-e2374bb8c7484fc196589113c5d3c3e8
出典データセット
uspto-grants-2008_09
特許番号
US07425631B2

反応ノート

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