HCID 68932625、化合物 → Methyl-(7-piperidin-1-ylmethyl-chroman-4-yl)-amine
反応式
C(O[C:6](=O)[N:7](C)[CH:8]1[C:17]2[C:12](=[CH:13][C:14]([CH2:18][N:19]3[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]3)=[CH:15][CH:16]=2)[O:11][CH2:10][CH2:9]1)(C)(C)C>Cl.CCOC(C)=O>[CH3:6][NH:7][CH:8]1[C:17]2[C:12](=[CH:13][C:14]([CH2:18][N:19]3[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]3)=[CH:15][CH:16]=2)[O:11][CH2:10][CH2:9]1参加物
3
実験手順
A mixture of methyl-(7-piperidin-1-ylmethyl-chroman-4-yl)-carbamic acid tert-butyl ester (567 mg, 1.58 mmol, 1.0 eq) in saturated HCl/EtOAc (15 mL) was stirred at RT for 7 h. The solvent was removed with a rotary evaporator. The crude was diluted with saturated Na2CO3 (60 mL), and extracted with EtOAc (60 mL×3). The extract phase was washed with saturated NaCl, dried over Na2SO4, filtered and concentrated. The title compound was obtained as orange oil. MS (ESI, pos. ion) m/z: 261 (M+1).
後処理
- customThe solvent was removed with a rotary evaporator
- addition