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2-[(Dimethylamino)methylidene]cyclohexane-1,3-dione → 2-(2-(tert-butyldiphenylsilyloxy)ethyl)-7,8-dihydroquinazolin-5(6H)-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-[(Dimethylamino)methylidene]cyclohexane-1,3-dione | HCID 359353 | — |
| 反応物 | 3-(Tert-butyldiphenylsilyloxy)propanamidine | HCID 58841407 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 2-(2-(tert-butyldiphenylsilyloxy)ethyl)-7,8-dihydroquinazolin-5(6H)-one | HCID 58841347 | — |
反応手順
A solution of 3-(tert-butyl-diphenyl-silanyloxy)-propionamidine (25 g, 77 mmol) and 2-dimethylaminomethylene-cyclohexane-1,3-dione (12.8 g, 77 mmol) in 400 mL of dry EtOH was heated at 80° C. for 3 h. After cooling to RT, the solvent was evaporated. Flash chromatography (SiO2, EtOAc/hexane=1:1) gave the desired compound as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07425631B2 |
| 出典データセット | uspto-grants-2008_09 |
| ORD ID | ord-1934d873284f448895a79663ca6cef26 |
| 出典メモ | uspto-grants-2008_09 |