Glyoxal, phenyl-, hydrate → 2-(3,5-Dichlorophenyl)-5-phenyl-2,3-dihydro-1,2,4-triazin-3-one

HRID 321980

反応式

HRID 321980 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([N:9]([C:11]([NH2:13])=[O:12])[NH2:10])[CH:5]=[C:6]([Cl:8])[CH:7]=1.O.[C:15]1([C:21]([CH:23]=O)=O)[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>O1CCOCC1>[Cl:1][C:2]1[CH:3]=[C:4]([N:9]2[C:11](=[O:12])[N:13]=[C:21]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[CH:23]=[N:10]2)[CH:5]=[C:6]([Cl:8])[CH:7]=1

参加物

4

反応物 2

HCID 12215922Glyoxal, phenyl-, hydrateHCID 155216502-(3,5-Dichlorophenyl)semicarbazide

生成物 1

HCID 155216512-(3,5-Dichlorophenyl)-5-phenyl-2,3-dihydro-1,2,4-triazin-3-one収率 42.2%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

In 50 ml of dioxane was dissolved 2.20 g of 2-(3,5-dichlorophenyl)semicarbazide followed by addition of 1.52 g of phenylglyoxal monohydrate, and the mixture was refluxed for 5 hours. The reaction mixture was then concentrated and the residue was recrystallized from acetonitrile to provide 1.34 g of the title compound. m.p. 160-161° C.

後処理

  1. temperaturethe mixture was refluxed for 5 hours
  2. concentrationThe reaction mixture was then concentrated
  3. customthe residue was recrystallized from acetonitrile

出典と根拠

ORDレコード
ord-97d8a8a988414f908a826ffd10fbc537
出典データセット
uspto-grants-2001_04
特許番号
US06211178B1

関連ノート

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