関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | 4-(Trifluoromethyl)cinnamic acid | HCID 688070 | — |
| 触媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 4-(Trifluoromethyl)cinnamoyl chloride | HCID 11107291 | — |
反応手順
200.0 mg (0.92 mmol) of trans-4-trifluoromethylcinnamic acid were treated with 200 μl of thionyl chloride. After addition of 2 drops of DMF, the reaction solution obtained was stirred at 75° C. for 3 h. It was then concentrated to dryness, and the residue was taken up in toluene 2× and concentrated to dryness again. Drying in a high vacuum yielded 237.0 mg of the title compound as a slightly yellow, amorphous powder.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06211196B1 |
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| 出典データセット | uspto-grants-2001_04 |
|---|
| ORD ID | ord-fc6c1c230be84f99a7c445e3d7914d02 |
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| 出典メモ | uspto-grants-2001_04 |
|---|
