Acetyl chloride → (S)-(+)-2-Phenylglycine methyl ester hydrochloride

HRID 322050

反応式

HRID 322050 の反応式
[C:1]([Cl:4])(=O)C.[CH:5]1[CH:10]=[CH:9][C:8]([C@@H:11]([NH2:15])[C:12]([OH:14])=[O:13])=[CH:7][CH:6]=1>CO>[CH3:1][O:13][C:12]([C@@H:11]([NH2:15])[C:8]1[CH:7]=[CH:6][CH:5]=[CH:10][CH:9]=1)=[O:14].[ClH:4]

参加物

4

反応物 2

HCID 6367Acetyl chlorideHCID 70134Phenylglycine, D-

生成物 1

HCID 11217910(S)-(+)-2-Phenylglycine methyl ester hydrochloride

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Acetyl chloride (4 ml) was added cautiously and dropwise to methanol (20 ml) at 0° C. over 2 minutes. When the addition was completed, D-phenylglycine (1 g, 5.9 mmol, Aldrich) was introduced in a single portion. The mixture was stirred until dissolved then allowed to stand at RT for 24 hours. The solvent was evaporated then coevaporated twice from toluene to afford the title compound as a white crystalline solid in quantitative yield. The title compound was obtained as a white crystalline solid in quantitative yield with an identical n.m.r. spectrum to the L-isomer.

後処理

  1. additionWhen the addition
  2. dissolutionuntil dissolved
  3. customThe solvent was evaporated

出典と根拠

ORDレコード
ord-92368913d9c2407190b644d8376d9a3c
出典データセット
uspto-grants-2001_04
特許番号
US06211212B1

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