3-(4-Pyridyl)aniline → 3-[3-(4-Pyridyl)Anilino]-3-Cyclobutene-1,2-Dione

HRID 322066ノート

反応式

HRID 322066 の反応式
[NH2:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=2)[CH:5]=[CH:6][CH:7]=1.C([O:18][C:19]1[C:20](=[O:24])[C:21](=O)[CH:22]=1)CCC>C(O)C>[N:11]1[CH:12]=[CH:13][C:8]([C:4]2[CH:3]=[C:2]([CH:7]=[CH:6][CH:5]=2)[NH:1][C:21]2[C:20](=[O:24])[C:19](=[O:18])[CH:22]=2)=[CH:9][CH:10]=1

参加物

4

反応物 2

HCID 4595233-(4-Pyridyl)anilineHCID 157231823-Butoxycyclobut-3-ene-1,2-dione

生成物 1

HCID 98378313-[3-(4-Pyridyl)Anilino]-3-Cyclobutene-1,2-Dione収率 76.8%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of 4-(3-aminophenyl)pyridine (0.81 g) and 3-n-butoxy-3-cyclobutene-1,2-dione (0.73 g) in ethanol (20 ml) is stirred at ambient temperature for 15 hours. The resultant precipitated solid is washed with methanol and ether and recrystallized from dimethyl formamide to give 0.91 g of the title compound, mp 252-255.5° C.

後処理

  1. customThe resultant precipitated solid
  2. washis washed with methanol and ether
  3. customrecrystallized from dimethyl formamide

出典と根拠

ORDレコード
ord-f402d218b9ee48c28e8843565ed69c3d
出典データセット
uspto-grants-2001_04
特許番号
US06211220B1

反応ノート

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