化工社化工社 化学情報印刷レポート · 研究参考用
Methyl 5-bromovalerate → Methyl 5-methoxypentanoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl 5-bromovalerate | HCID 79557 | — |
| 反応物 | Sodium Methoxide | HCID 10942334 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | Methyl 5-methoxypentanoate | HCID 542362 | 97.8% |
反応手順
A solution of methyl 5-bromovalerate (10.0 g, 51.3 mmol), NaOMe (12.3 ml of 25% solution, 53.8 mmol) in 100 ml of MeOH was refluxed for 5 hrs. The MeOH was removed in vacuo and residue was partitioned between CHCl3 (200 ml) and water (50 ml). The organic layer was separated and washed with water (100 ml). After drying (Na2SO4) and evaporation of solvent, methyl 5-methoxyvalerate (7.33 g, 97.8%) was obtained as a colorless oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06211198B1 |
| 出典データセット | uspto-grants-2001_04 |
| ORD ID | ord-60de5e01bedc4fce95603dab88626cfd |
| 出典メモ | uspto-grants-2001_04 |