Triethylamine → 4-[4-(Benzyloxy)phenyl]butyl methanesulfonate
反応式
[CH3:1][S:2](Cl)(=[O:4])=[O:3].[CH2:6]([O:13][C:14]1[CH:19]=[CH:18][C:17]([CH2:20][CH2:21][CH2:22][CH2:23][OH:24])=[CH:16][CH:15]=1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.C(N(CC)CC)C>C(OCC)(=O)C>[CH3:1][S:2]([O:24][CH2:23][CH2:22][CH2:21][CH2:20][C:17]1[CH:16]=[CH:15][C:14]([O:13][CH2:6][C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=2)=[CH:19][CH:18]=1)(=[O:4])=[O:3]参加物
5
実験手順
Methanesulfonyl chloride (17.9 g) was added to a solution of 4-(4-benzyloxyphenyl)butanol (20.0 g) and triethyl amine (15.8 g) in ethyl acetate (500 ml) at 0° C. and then stirred for 5 hours at room temperature. The reaction mixture was washed with water, dried (MgSo4) and concentrated under reduced pressure to give 4-(4-benzyloxyphenyl)butyl methanesulfonate (26.0 g, quantitatively). Oily substance.