Imidazole → 5-[3-(1-Imidazolyl)propyl]-2-methoxypyridine

反応式

CS(O[CH2:6][CH2:7][CH2:8][C:9]1[CH:10]=[CH:11][C:12]([O:15][CH3:16])=[N:13][CH:14]=1)(=O)=O.[NH:17]1[CH:21]=[CH:20][N:19]=[CH:18]1>>[N:17]1([CH2:6][CH2:7][CH2:8][C:9]2[CH:10]=[CH:11][C:12]([O:15][CH3:16])=[N:13][CH:14]=2)[CH:21]=[CH:20][N:19]=[CH:18]1

参加物

反応物 2

HCID 795Imidazole

HCID 220098553-(2-Methoxy-5-pyridyl)propyl methanesulfonate

生成物 1

HCID 220098285-[3-(1-Imidazolyl)propyl]-2-methoxypyridine収率 94%

実験手順

In substantially the same manner as in Reference Example 88, 3-(2-methoxy-5-pyridyl)propyl methanesulfonate was reacted with imidazole to give 5-[3-(1-imidazolyl)propyl]-2-methoxypyridine. The yield was 94%. Oily substance.

出典と根拠

ORDレコード: ord-8cf39828ca28470dbd7712c81e05996f
出典データセット: uspto-grants-2001_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06211215B1

反応ノート

読み込み中…