Imidazole → HCID 22009692、化合物

反応式

[NH:1]1[CH:5]=[CH:4][N:3]=[CH:2]1.CS(O[CH2:11][CH2:12][CH2:13][C:14]1[CH:19]=[CH:18][C:17]([O:20][CH2:21][C:22]2[N:23]=[C:24](/[CH:27]=[CH:28]/[C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[O:25][CH:26]=2)=[C:16]([O:35][CH3:36])[CH:15]=1)(=O)=O>>[N:1]1([CH2:11][CH2:12][CH2:13][C:14]2[CH:19]=[CH:18][C:17]([O:20][CH2:21][C:22]3[N:23]=[C:24](/[CH:27]=[CH:28]/[C:29]4[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=4)[O:25][CH:26]=3)=[C:16]([O:35][CH3:36])[CH:15]=2)[CH:5]=[CH:4][N:3]=[CH:2]1

参加物

反応物 2

HCID 795Imidazole

HCID 22009860HCID 22009860、化合物

生成物 1

HCID 22009692HCID 22009692、化合物収率 60%

実験手順

In substantially the same manner as in Working Example 8, imidazole was allowed to react with 3-[3-methoxy-4-[2-[(E)-2-phenylethenyl]-4-oxazolylmethoxy]phenyl]propyl methanesulfonate to give 4-[4-[3-(1-imidazolyl)propyl]-2-methoxyphenoxymethyl]-2-[(E)-2-phenylethenyl]oxazole. The yield was 60%. Recrystallization from ethyl acetate-hexane gave colorless prisms, m,p.95-96° C.

出典と根拠

ORDレコード: ord-6513ecb93b144c06b4be3298abef8e92
出典データセット: uspto-grants-2001_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06211215B1

反応ノート

読み込み中…