化工社化工社 化学情報印刷レポート · 研究参考用
1-[3-(3-Hydroxyphenyl)propyl]imidazole → 2-(4-Benzyloxyphenyl)-4-[3-[3-(1-imidazolyl)propyl]phenoxymethyl]oxazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-[3-(3-Hydroxyphenyl)propyl]imidazole | HCID 22009809 | — |
| 反応物 | 2-(4-Benzyloxy-phenyl)-4-chloromethyl-oxazole | HCID 22009845 | — |
| 生成物 | 2-(4-Benzyloxyphenyl)-4-[3-[3-(1-imidazolyl)propyl]phenoxymethyl]oxazole | HCID 22009625 | 81% |
反応手順
In substantially the same manner as in Working Example 72, 1-[3-(3-(3-hydroxyphenyl)propyl]imidazole was allowed to react with 2-(4-benzyloxyphenyl)-4-chloromethyloxazole to give 2-(4-benzyloxyphenyl)-4-[3-[3-(1-imidazolyl)propyl]phenoxymethyl]oxazole. The yield was 81%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 144-145° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06211215B1 |
| 出典データセット | uspto-grants-2001_04 |
| ORD ID | ord-b40a9129cf504fcc8cbcba254d087a33 |
| 出典メモ | uspto-grants-2001_04 |