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HRID 322407作成日：2026年10月25日

1-[4-(3-Hydroxyphenyl)butyl]imidazole → 2-(4-Benzyloxyphenyl)-4-[3-[4-(1-imidazolyl)butyl]phenoxymethyl]oxazole

https://huagongshe.com/reaction/322407

反応式

関与物質

役割名称HCID仕込み量
反応物1-[4-(3-Hydroxyphenyl)butyl]imidazoleHCID 22009661—
反応物2-(4-Benzyloxy-phenyl)-4-chloromethyl-oxazoleHCID 22009845—
生成物2-(4-Benzyloxyphenyl)-4-[3-[4-(1-imidazolyl)butyl]phenoxymethyl]oxazoleHCID 2200967578%

反応手順

In substantially the same manner as in Working Example 72, 1-[4-(3-hydroxyphenyl)butyl]imidazole was allowed to react with 2-(4-benzyloxyphenyl)-4-chloromethyloxazole to give 2-(4-benzyloxyphenyl)-4-[3-[4-(1-imidazolyl)butyl]phenoxymethyl]oxazole. The yield was 78%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 87-88° C.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US06211215B1
出典データセットuspto-grants-2001_04
ORD IDord-03c85665c5d446708c377b40e1b2cb77
出典メモuspto-grants-2001_04