1-[4-(3-Hydroxyphenyl)butyl]imidazole → HCID 22009687、化合物

HRID 322411

反応式

HRID 322411 の反応式
[OH:1][C:2]1[CH:3]=[C:4]([CH2:8][CH2:9][CH2:10][CH2:11][N:12]2[CH:16]=[CH:15][N:14]=[CH:13]2)[CH:5]=[CH:6][CH:7]=1.Cl[CH2:18][C:19]1[CH:20]=[CH:21][C:22]2[O:26][C:25]([C:27]3[S:28][CH:29]=[CH:30][CH:31]=3)=[N:24][C:23]=2[CH:32]=1>>[N:12]1([CH2:11][CH2:10][CH2:9][CH2:8][C:4]2[CH:3]=[C:2]([CH:7]=[CH:6][CH:5]=2)[O:1][CH2:18][C:19]2[CH:20]=[CH:21][C:22]3[O:26][C:25]([C:27]4[S:28][CH:29]=[CH:30][CH:31]=4)=[N:24][C:23]=3[CH:32]=2)[CH:16]=[CH:15][N:14]=[CH:13]1

参加物

3

反応物 2

HCID 220096611-[4-(3-Hydroxyphenyl)butyl]imidazoleHCID 220097205-Chloromethyl-2-(2-thienyl)benzoxazole

生成物 1

HCID 22009687HCID 22009687、化合物収率 70%

実験手順

In substantially the same manner as in Working Example 72, 1-[4-(3-hydroxyphenyl)butyl]imidazole was allowed to react with 5-chloromethyl-2-(2-thienyl)benzoxazole to give 5-[3-[4-(1-imidazolyl)butyl]phenoxymethyl]-2-(2-thienyl)benzoxazole. The yield was 70%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 97-98° C.

出典と根拠

ORDレコード
ord-d070bcd1c4a9497d8ba8cac2d29dda97
出典データセット
uspto-grants-2001_04
特許番号
US06211215B1

関連ノート

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