1-[3-(4-Hydroxyphenyl)propyl]imidazole → HCID 54312791、化合物
反応式
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][N:11]2[CH:15]=[CH:14][N:13]=[CH:12]2)=[CH:4][CH:3]=1.Cl[CH2:17][C:18]1[N:19]=[C:20]([C:23]2[S:24][C:25]3[CH2:31][CH2:30][CH2:29][CH2:28][C:26]=3[CH:27]=2)[O:21][CH:22]=1>>[N:11]1([CH2:10][CH2:9][CH2:8][C:5]2[CH:6]=[CH:7][C:2]([O:1][CH2:17][C:18]3[N:19]=[C:20]([C:23]4[S:24][C:25]5[CH2:31][CH2:30][CH2:29][CH2:28][C:26]=5[CH:27]=4)[O:21][CH:22]=3)=[CH:3][CH:4]=2)[CH:15]=[CH:14][N:13]=[CH:12]1参加物
3
実験手順
In substantially the same manner as in Working Example 72, 1-[3-(4-hydroxyphenyl)propyl]imidazole was allowed to react with 4-chloromethyl-2-(4,5,6,7-tetrahydro-2-benzothienyl)oxazole to give 4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]-2-(4,5,6,7-tetrahydro-2-benzothienyl)oxazole. The yield was 70%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 83-84° C.
出典と根拠
- ORDレコード
- ord-5617f3c56864447fa28cf7a1cea9be4f
- 出典データセット
- uspto-grants-2001_04
- 特許番号