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4-Chloromethyl-2-(2-furyl)oxazole → 2-(2-Furyl)-4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]oxazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Chloromethyl-2-(2-furyl)oxazole | HCID 22009706 | — |
| 反応物 | 1-[3-(4-Hydroxyphenyl)propyl]imidazole | HCID 22009818 | — |
| 生成物 | 2-(2-Furyl)-4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]oxazole | HCID 22009821 | 31% |
反応手順
In substantially the same manner as in Working Example 109, 1-[3-(4-hydroxyphenyl)propyl]imidazole was allowed to react with 4-chloromethyl-2-(2-furyl)oxazole to give 2-(2-furyl)-4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]oxazole. The yield was 31%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 92-93° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06211215B1 |
| 出典データセット | uspto-grants-2001_04 |
| ORD ID | ord-fdd8f8e2ef8d4e82af015f3fac9cc0f2 |
| 出典メモ | uspto-grants-2001_04 |