1-[3-(4-Hydroxyphenyl)propyl]imidazole → HCID 22009869、化合物

反応式

[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][N:11]2[CH:15]=[CH:14][N:13]=[CH:12]2)=[CH:4][CH:3]=1.Cl[CH2:17][C:18]1[CH:19]=[CH:20][C:21]2[O:25][C:24]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)=[N:23][C:22]=2[CH:32]=1>>[N:11]1([CH2:10][CH2:9][CH2:8][C:5]2[CH:6]=[CH:7][C:2]([O:1][CH2:17][C:18]3[CH:19]=[CH:20][C:21]4[O:25][C:24]([C:26]5[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=5)=[N:23][C:22]=4[CH:32]=3)=[CH:3][CH:4]=2)[CH:15]=[CH:14][N:13]=[CH:12]1

参加物

反応物 2

HCID 220098181-[3-(4-Hydroxyphenyl)propyl]imidazole

HCID 69567430HCID 69567430、化合物

生成物 1

HCID 22009869HCID 22009869、化合物収率 67%

実験手順

In substantially the same manner as in Working Example 109, 1-[3-(4-hydroxyphenyl)propyl]imidazole was allowed to react with 5-chloromethyl-2-phenylbezoxazole to give 5-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]-2-phenylbenzoxazole. The yield was 67%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 137-138° C.

出典と根拠

ORDレコード: ord-40c57d5a949b4520bf6e3f2b67378c5b
出典データセット: uspto-grants-2001_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06211215B1

反応ノート

読み込み中…

参加物