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6-Bromo-2-(chloromethyl)imidazo[1,2-a]pyridine → 6-Bromo-2-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]imidazo[1,2-a]pyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 6-Bromo-2-(chloromethyl)imidazo[1,2-a]pyridine | HCID 11622894 | — |
| 反応物 | 1-[3-(4-Hydroxyphenyl)propyl]imidazole | HCID 22009818 | — |
| 生成物 | 6-Bromo-2-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]imidazo[1,2-a]pyridine | HCID 22009851 | 57% |
反応手順
In substantially the same manner as in Working Example 109, 1-[3-(4-hydroxyphenyl)propyl]imidazole was allowed to react with 6-bromo-2-chloromethylimidazo[1,2-a]pyridine to give 6-bromo-2-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]imidazo[1,2-a]pyridine. The yield was 57%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 103-104° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06211215B1 |
| 出典データセット | uspto-grants-2001_04 |
| ORD ID | ord-d7bb8b1d28d846d68bd82fd358c0148f |
| 出典メモ | uspto-grants-2001_04 |