4-(Chloromethyl)-2-(thiophen-2-yl)-1,3-oxazole → 4-[2-Chloro-4-[3-(1-imidazolyl)propyl]phenoxymethyl]-2-(2-thienyl)oxazole
反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][CH2:10][CH2:11][N:12]2[CH:16]=[CH:15][N:14]=[CH:13]2)[CH:5]=[CH:6][C:7]=1[OH:8].Cl[CH2:18][C:19]1[N:20]=[C:21]([C:24]2[S:25][CH:26]=[CH:27][CH:28]=2)[O:22][CH:23]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][CH2:10][CH2:11][N:12]2[CH:16]=[CH:15][N:14]=[CH:13]2)[CH:5]=[CH:6][C:7]=1[O:8][CH2:18][C:19]1[N:20]=[C:21]([C:24]2[S:25][CH:26]=[CH:27][CH:28]=2)[O:22][CH:23]=1参加物
3
実験手順
In substantially the same manner as in Working Example 72, 1-[3-(3-chloro-4-hydroxyphenyl)propyl]imidazole was reacted with 4-chloromethyl-2-(2-thienyl)oxazole to obtain 4-[2-chloro-4-[3-(1-imidazolyl)propyl]phenoxymethyl]-2-(2-thienyl)oxazole. The yield was 77%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 93-94° C.
出典と根拠
- ORDレコード
- ord-221b0a892f9847e5a2fd8012911e071c
- 出典データセット
- uspto-grants-2001_04
- 特許番号
- US06211215B1
反応ノート
読み込み中…