5-(Chloromethyl)-3-phenyl-1,2,4-oxadiazole → HCID 22009808、化合物

HRID 322475ノート

反応式

HRID 322475 の反応式
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][N:11]2[CH:15]=[CH:14][N:13]=[CH:12]2)=[CH:4][CH:3]=1.Cl[CH2:17][C:18]1[O:22][N:21]=[C:20]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[N:19]=1>>[N:11]1([CH2:10][CH2:9][CH2:8][C:5]2[CH:6]=[CH:7][C:2]([O:1][CH2:17][C:18]3[O:22][N:21]=[C:20]([C:23]4[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=4)[N:19]=3)=[CH:3][CH:4]=2)[CH:15]=[CH:14][N:13]=[CH:12]1

参加物

3

反応物 2

HCID 9667145-(Chloromethyl)-3-phenyl-1,2,4-oxadiazoleHCID 220098181-[3-(4-Hydroxyphenyl)propyl]imidazole

生成物 1

HCID 22009808HCID 22009808、化合物収率 51%

実験手順

In substantially the same manner as in Working Example 72, 1-[3-(4-hydroxyphenyl)propyl]imidazole was reacted with 5-chloromethyl-3-phenyl-1,2,4-oxadiazole to obtain 5-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]-3-phenyl-1,2,4-oxadiazole. The yield was 51%. Recrystallization from ethyl acetate-hexane gave colorless needles, mp 124-125° C.

出典と根拠

ORDレコード
ord-e96274777f7c40f3ae3b13fbf018a3a9
出典データセット
uspto-grants-2001_04
特許番号
US06211215B1

反応ノート

読み込み中…