化工社化工社 化学情報印刷レポート · 研究参考用
Methanol → (S,R)-N-[4-(3-trifluoromethoxyphenyl)-2-butyl]-1-(1-naphthyl)ethylamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | (+)-1-(1-Naphthyl)ethylamine | HCID 2724264 | — |
| 反応物 | Sodium cyanoborohydride | HCID 5003444 | — |
| 反応物 | 4-(3-Trifluoromethoxyphenyl)-2-butanone | HCID 23506055 | — |
| 触媒 | Titanium isopropoxide | HCID 11026 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | (S,R)-N-[4-(3-trifluoromethoxyphenyl)-2-butyl]-1-(1-naphthyl)ethylamine | HCID 69711187 | — |
反応手順
In a similar fashion an equal molar amount of 4-(3-trifluoromethoxyphenyl)-2-butanone, (R)-1-(1-naphthyl)ethylamine and 1.25 equivalents titanium(IV) isopropoxide were mixed and the intermediate imine reduced with ethanolic sodium cyanoborohydride. Work-up and repetitive preparative thin-layer chromatography using 5% methanol in chloroform afforded (S,R)-N-[4-(3-trifluoromethoxyphenyl)-2-butyl]-1-(1-naphthyl)ethylamine, 22X; m/z (rel. int.) 387 (M+, 3), 372 (15), 198 (15), 176 (12), 155 (100), 128 (8), 115 (6), 109 (4), 103 (5), 77 (8) and (R,R)-N-[4-(3-trifluoromethoxyphenyl)-2-butyl]-1-(1-naphthyl)ethylamine, 22Y; m/z (rel. int.) 387 (M+, 2), 372 (12), 198 (16), 176 (11), 155 (100), 128 (8), 115 (6), 109 (4), 103 (5), 77 (8).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06211244B1 |
| 出典データセット | uspto-grants-2001_04 |
| ORD ID | ord-1675c62384724056add36f5f51261cda |
| 出典メモ | uspto-grants-2001_04 |